Rev. Méd. RosaRio 88: 55, 2023
RESÚMENES DE PUBLICACIONES
EFFECT OF TERIPARATIDE ON BONE MINERAL DENSITY AND BONE MARKERS IN REAL-LIFE:
ARGENTINE EXPERIENCE
Rodolfo GuelMan, aRiel sánchez, MaRiela vaRsavsky, lucas R. BRun, MaRía lauRa GaRcía,
MaRcelo saRli, Paula Rey, vanina faRías, MaRía Belén zanchetta, evanGelina Giacoia, helena
saleRni, lauRa Maffei. valeRia PReMRou, BeatRiz oliveRi, MaRía loRena BRance, MaGdalena
Pavlove, silvia kalRsBRuM, MaRía silvia laRRoudé, PaBlo René costanzo.
Purpose. To evaluate the efect of teriparatide than LS (just at month 12), reaching a maximum peak
(
TPTD) on bone mineral density (BMD) and bone at month 24 (FN + 7.9% and TH + 5.5%). A signifcant
markers under clinical practice conditions. To assess increase in LS BMD was found from month 6 to
whether the results in real-life match those published month 24 compared to basal in both AR-na¨ıve, and
in clinical trials. Methods. Cross-sectional study of AR-prior patients (+16.7% and +1ꢀ.5%, respectively),
postmenopausal women treated with TPTD for at least without signifcant diferences between the two groups.
12 months. Results. 264 patients were included in the Comparable results were found in FN and TH BMD.
study. Main characteristics are as follows: age: 68.7 ± 1ꢀ.2 Main conclusions. As reported in real-life clinical studies,
years, previous fractures: 57.6%, and previously treated treatment of osteoporotic postmenopausal women with
with antiresorptive (ARprior): 79%. All bone turnover TPTD induced a signifcant increase in bone turnover
markers studied signifcantly increased after 6 months. markers from month 6 onward and an increase in BMD
CTX and BGP remained high up to 24 months, but total from months 6–12 with continuous gain up to month
and bone alkaline phosphatase returned to basal values at 24. Te real-life results of our study matched the results of
month 18. Tere was a signifcant increase in lumbar spine randomized clinical trials. In addition, TPTD induced an
(LS) BMD after 6 months (+6.2%), with a maximum increase in BMD, regardless of the previous use of AR.
peak at 24 months (+13%). Femoral neck (FN) and
total hip (TH) BMD showed a signifcant increase later
Int J Endocrinol 2023, Article 93672
REVISTA MÉDICA DE ROSARIO
55